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Sytrinol® Where-to-buy2015


NPN 80033137

  • Lower Total Cholesterol
  • Lower LDL Cholesterol

What is Sytrinol?

Cardiovascular diseases are the leading cause of death in Canada. One of the biggest risk factors is high cholesterol. Studies have shown that Sytrinol is able to lower your total cholesterol, bad cholesterol (LDL), and triglycerides in 30 days. Sytrinol has also been shown to increase good cholesterol (HDL) levels.

Sytrinol is a powerful antioxidant with numerous heart health benefits. Sytrinol is a patented formula derived from natural citrus and palm fruit extracts. It combines polymethoxylated flavones (PMFs), delta, gamma, and alpha tocotrienols.

Clinical trials have shown that Sytrinol acts synergistically to improve total cholesterol by 30%, lower LDL cholesterol by 27%, and reduce triglycerides by 34% (compared to a placebo). Sytrinol has also been shown to increase HDL levels. To date three major studies have been carried out to investigate Sytrinols effects on cholesterol levels.

The first study involved 60 participants with raised cholesterol levels. After taking 300mg of Sytrinol each day for four weeks, the researchers found that the treatment lowered total cholesterol by 25%, the bad LDL cholesterol by 19%, and triglycerides by 24%.

In the second, smaller study 10 subjects with elevated cholesterol levels benefited after four weeks of treatment with 300mg of Sytrinol per day. Sytrinol therapy lowered total cholesterol levels by 20%, LDL cholesterol by 22%, apolipoprotein B (a component of LDL) by 21%, and triglycerides by 28%. Additionally, subjects in this trial benefitted from a significant 5%increase in apolipoprotein A1 an important structural protein of the good HDL cholesterol.

A third clinical trial involved 120 patients with moderately elevated cholesterol levels. Compared to the placebo group, subjects taking Sytrinol had a decrease of 30% in total cholesterol, 27% in LDL cholesterol, and 34% in triglycerides. In addition, HDL levels increased by 4 per cent, resulting in a significant 29% improvement in the LDL: HDL ratio.



Medicinal Ingredients
  • Mandarin Orange Extract (citrus nobilis) (peel) (36% Polymethoxylated Flavones)................ 270 mg
  • Palm Extract (Elaeis guineensis) (seed oil) (15% Tototrienols)................ 30 mg
  • Non-Medicinal Ingredients
  • Microcrystalline cellulose, vegetarian capsule (cellulose, purified water, silica), silica, L-leucine, palm oil, gum arabic, malthodextrin.

CAUTION: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Keep out of reach of children.


1 capsule daily or as directed by a health care practitioner.
Use for a minimum of 4 weeks to see beneficial results. Consult a health care practitioner for use beyong 12 weeks.

This product does not contain artificial preservatives, colour or sweeteners; dairy, soy, wheat or yeast.

If I start taking Sytrinol, can I stop taking Lipitor?

No one, except a Medical or Naturopathic Doctor, can recommend that a person stop taking their prescribed medication.  Sytrinol is NOT a replacement for a statin drug.  It can be taken in conjunction with a statin, but patients need to be monitored carefully by a Health Care professional when weaning off of ANY type of medication.

I have been taking Sytrinol for awhile and my cholesterol levels haven't changed.  Why could this be?

Everyone is individually unique, and what may work well for one person might not for another, yet Sytrinol does have an over 87% success rate.  Sytrinol works by lowering LDL (the bad cholesterol) and triglycerides, while boosting levels of the health HDL cholesterol.  It also works by controlling the degradation rate of the HMG-CoA reductase enzyme.  This enzyme is required for cholesterol synthesis in the liver.  However, healthy lifestyle practices, dietary changes (increase amount of vegetables and reduce sugar consumption), exercise and stress management are all factors that play a key role in healthy cholesterol levels (and in the prevention of heart disease and stroke).  If you are concerned about your cholesterol levels, then we highly recommend you discuss this with your Health Care practitioner.

Am I supposed to take Sytrinol every day and if so, how long should I take it for?

Yes, Sytrinol should be taken daily (no breaks are necessary) and there is no limit on how long this product can be taken for.  We do however recommend that you take Sytrinol with your ND's or GP's knowledge and have your cholesterol checked approximately every 12 weeks.

I'm confused as to why I can take Lipitor along with Sytrinol, which is made from a citrus fruit - but I can't take Lipitor with grapefruit, which is another citrus fruit?  Can you please explain?

Grapefruit contains the compound bergamottin, which interacts with certain enzyme systems in the body, such as cytochrome P-450 and P-glycoprotein.  These enzymes systems are responsible for breaking down statins, as well as other drugs, into more usable chemicals and transporting them in the body.  When grapefruit is consumed, the components in the grapefruit prevent these enzyme systems from breaking down the drug, causing the drug to accumulate in high amounts in the body.  So far research has only isolated grapefruit as the one citrus fruit that interferes with that specific enzyme system.

What is the source of the "natural citrus" in this product?

The source is polymethoxylated flavones from Mandarin orange (Citrus nobilis).

Are "palm tocotrienols" the same as palm oil?

No, they are different.  Also, Sytrinol uses palm from sustainable green source in Malaysia, the only sustainable palm in the world. 

Is the palm in this product strong enough to be a blood thinner?

The palm in this product is fruit tocotrienols and there is no blood thinning action whatsoever.

Can Sytrinol be taken with plant sterols?

It is best to take Sytrinol alone as there is reason to believe that phytosterols interfere with the absorption of the active ingredients in Sytrinol.

For best results, is it better to take this product in the AM or PM?

It does not matter what time of day Sytrinol is taken.

Can I increase from one capsule per day to two per day?

We do recommend only one capsule per day, however with your Health Care Practitioner's approval, there is no reason you couldn't increase to two per day for a 6-month period and then re-test your cholesterol levels.

Why has a caution been added to your label to consult my health care practitioner for use beyond 12 weeks?

The initial study done with Sytrinol was a 12-week study and because of this, Health Canada required the caution to be added to our labels.  This warning should be regarded as a monitoring parametre - that at the 12-week mark, a consumer can request that their cholesterol be checked to ensure everything is fine.

Is Sytrinol hard on the liver?  (as compared to prescription medications, for example)

From the research done on Sytrinol, it is safe to say that Sytrinol works very differently from statin drugs and other cholesterol lowering medications with respect to the liver - but if there is an ongoing issue, then a person should continue to monitor their liver enzymes with their Health Care practitioner while taking Sytrinol.

I find that I get muscle pain from statin drugs.  Does Sytrinol have this same side effect?

No.  The mechanism of action of Sytrinol is very different from statin medications and therefore does not cause muscle pain or any other common side effects associated with statins or other heart medications.

Do I have access to the clinical studies done on Sytrinol?

Yes - please visit Sytrinol's website at and click on either "research" or "articles" for more information and to view the documented studies.

Is Sytrinol gluten free?

Because Sytrinol is a 3rd party product (arrives as a finished product from the USA and then is packaged in Canada) we can confirm that yes it is gluten free, and there is no possibility of cross-contamination during the manufacturing process.

Do all of your products have an NPN?

Yes, all of our products have been issued a Natural Product Number (NPN) by Health Canada – these numbers do appear on our labels.  Further Natural Health Product criteria and information can be found on the Health Canada website  Under the Food and Drugs Act items that are considered a food – for example, our protein powders and herbal teas – do not require an NPN.  

Are your capsules GMO free?

Yes, our vegetarian capsule shells, our gelatin capsule shells and our softgel shells are all non-GMO.

Are your products GMO free?

Preferred Nutrition is currently in the process of testing all of our products so that we can advise the public if any of them contain ingredients that come from genetically modified organisms or not.  Once the testing is complete we will indicate on our website, as well as on our product information sheets and on our labels.  This will be done as quickly as possible and on a product-by-product basis.

Why have your cautions and your recommended/suggested usages changed so dramatically on many of your labels?

The changes you are noticing to our suggested usage and cautionary statements have been at the directive of Health Canada.  There have been many regulatory changes with regards to Natural Health Products causing companies to change their labels accordingly.  We update our website, product information sheets and labels on the actual products to reflect these regulations as quickly as we possibly can.  Health Canada and the industry representing natural health products act according to the interest of consumers and their safety.  As a result, if there is any concern with an existing condition, a caution is added to advise the consumer to seek out feedback from their Health Care professional. 

Will this product help me lose weight?

There is no such thing as a "magic" pill or product - the only way to succeed (and maintain) true weight loss is by adopting a healthy lifestyle combining adequate exercise and proper nutrition. If you are concerned about poor eating habits or cravings, then we recommend you seek advice from a Nutritionist or Naturopath to obtain some guidance on healthy eating, as well as to investigate possible underlying (or undiagnosed) hormonal imbalances, which can make it harder to lose weight.  You might also want to consider speaking with a personal trainer to help you discover a fun fitness program that you enjoy - because, no matter what, in order to achieve and maintain any type of weight loss, exercise is required.  Our vitamins and supplements are designed to help you in your quest to a daily, healthy lifestyle, however it also requires effort on your part.

Where do you source your products from?

Please be advised that all of our ingredients, including flavourings, are derived from natural ingredients and are ISURA tested & certified (in order to ensure the absence of GMOs, contaminants, heavy metals and adulteration).  All of our products are manufactured at a GMP facility certified by Health Canada.  All raw materials come in and are tested for purity, safety and potency.  If they do not meet our standards they are rejected and sent back or destroyed.  We use the highest quality ingredients available, and choose organic whenever we can.  Many of our products contain proprietary patented ingredients that have been clinically researched to help deliver optimal results and outstanding quality.

Are your products peanut free?

Following compliance with food regulations, in order to make a negative claim such as "peanut free", it would be necessary to insure a zero tolerance of any peanut traces, including the possibility of cross contamination.  Although our manufacturing facility has a policy in place for allergen control, there is no specific policy for peanuts, nor is there a specific "no peanut agreement" with our raw material suppliers.

Can your products be used after the expiry date has passed?

Supplements generally keep their potency long after the expiry date.  There is certainly no safety issues with consuming after the expiry date has passed however the potency degrades over longer periods of time.

If a product does not specify "vegetarian capsule", then what is it made from?

These capsules are gelatin capsules sourced from either pork or beef.

Are any of your products "vegan-friendly"?

Yes, AdrenaSense, EstroSense, MenoSense, BioSil, Medi-C Plus, Magnesium and MagSense (from our WomenSense and Preferred Nutrition product lines), the Healing Teas, our Ultimate Maca Energy products and the Ultimate VEGAN line are all vegan friendly.

Why can't I find any prices on your website?

Preferred Nutrition is the wholesale distribution company for the products on this website. However we sell exclusively to Health Food stores & selected Natural Pharmacies across Canada, not directly to the general public.  Because the prices of our products can vary from store-to-store, we are unable to list our suggested prices on our website.  We recommend you contact your local retailer and inquire about prices directly with them.

Can I purchase products directly from you?  I went to a health food store and the prices seem very expensive.

We distribute our products in Canada only and we sell directly to Health Food stores - since they have a personal commitment to the natural health lifestyle.  Consumers are then able to buy our products from knowledgeable staff that are genuinely interested in helping people be well - people who care!  Always be sure to look for in store promotions or coupons when you are making your purchases as this can help alleviate your cost concerns.

Do all health food stores carry all of your products?

To find Health Food stores in your area that carry our products, please click on "Store Locator" at the top of this screen.  All you have to do is enter your postal code and you will be given a list of retailers in the radius that you choose. We do recommend calling ahead to see if they stock the item you are looking for and in most cases if a store does not normally carry something, they will offer to do a special order for you.

Are any of your products tested on animals?

No, there is no animal testing on any of our products.

Should your supplements be taken with or without food?

Most of our products will specify directly on the bottle whether they should be taken with a meal or not.  If nothing is stated, then the choice is yours as to when the best time is for you to take them.  In general, however, most vitamin supplements should be taken with food because once eating starts the digestive process, enzymes and gastric juices are generated and usually the nutrients will be absorbed and assimilated better.

I like the sound of many of your products.  Am I able to take different formulas at the same time?

Yes, it's safe to combine various WomenSense products to help support the body in achieving optimal health.  The same applies to the Preferred Nutrition line, Dr. Whitaker's formulas and Brad King's.  If you are unsure of any combination, then please consult your Health Care Practitioner.

I have heard that drinking green tea along with my supplements will end up flushing out all the nutrients?  Is this true?

No, you are fine taking your supplements with green tea.  Coffee inhibits the absorption of nutrients, but the caffeine in green tea will not pose the same problem.

Can you tell me if I can combine any of your supplements with the medication(s) I am on, as prescribed by my doctor?

It is best to consult your Doctor or alternative Health Practitioner before taking any new supplements while on prescribed medication.  If you have been approved to add our supplement(s) to your daily regime, then we do recommend that you space the medication and the supplements out by at least one hour.

Can I take your products when I am pregnant or breastfeeding?

We are not able to make any recommendations with any of our products when it comes to pregnancy or while nursing.  You must contact your Health Practitioner, Naturopath or Pharmacist.

I understand that you put a recommended dosage on your labels, but I can take more or less than that, right?  And, really, do I have to take the product every day?

With regards to the recommended dosage, we would suggest you speak to your Doctor or Health Care Practitioner before increasing any amounts.  As with any supplement you can determine your amount based on your personal preference - if you find that a product works for you immediately then you should be fine to take it just on the days you feel you need it, but again we suggest you discuss this with you MD or HP.  Some consumers find that a product needs to be in their system for a few days to a few weeks before they notice results and/or feel the full benefits.

I don't understand why when I purchase your product and open the bottle, the contents don't even fill 1/2 of the packaging that is being used?

The containers we use are determined based on product fill and required label information, as well as capsule count when/where applicable.  Sometimes we do have to use a larger bottle than seems necessary because of the information required on the labels - requirements both from Health Canada and in order for the label to be clear and legible to our consumers.  Also, in a case where we are offering larger volume (ie/ 400g versus 200g or 180 capsules versus 90 capsules), then we have to put the contents in a bigger container in order for there to be differentiation on the shelf.

I bought a bottle of your product, and although it seemed to feel lighter than usual, I didn't think much of it, until I opened the bottle and discovered that there is nowhere near the amount of capsules inside as there should have been.  How can this happen?

As part of our corporate policy and Good Manufacturing Practices (GMP) requirement, our procedures incorporate routine in-process checks plus a final examination of the finished product to ensure conformance to all aspects of quality, including correct product count.  There are a number of checks and balances performed by both Production and Quality Assurance personnel prior to, during, and after the packaging operations to ensure that product under-counts do not happen. Although product under-counts can happen, this occurrence is rare.  Should you discover that your bottle is far below the label claim count upon opening - we recommend you return it to your point of purchase as per our 100% customer satisfaction guarantee.

What is your 100% money-back (customer satisfaction) guarantee?

Our 100% money-back/customer satisfaction guarantee ensures that if a customer is not completely satisfied with their purchase, they can return the unused portion of the product (in its original packaging) back to their point of purchase and we will credit the Health Food store 100% of their purchase price from us.  We cannot dictate if a store will give cash back or an in-store credit, nor can we override store policies already in place ~ but we do promise to credit them, regardless of the reason for the return.


1.     Sytrinol - Bullet Points 2013.

2.   James M. Roza, Zheng Xian-Liu, Najla Guthrie; Effects of Citrus Flavinoids and Tocotrienols on Serum Cholestoral Levels in Hypercholesterolemic Subjects.

3.     DC Crowley, EM Kurowska, P Chaturvedi, N Guthrie; The Pharmacokinetics of Three SytrinolTM Formulations in Healthy Human Adults

4.     JNA Ajuluchukwu, NU Okubadejo, M Mabayoje, FJ Ojni, RN Okwudiafor, AC Mbakwem, OA Fasannade, DA Oke; Comparitive Study of the Effect of Tocotrienols and a-Tocopherol on Fasting Serum Lipid Profiles in Patients with Mild Hypercholesterolaemia: A Preliminary Report

5. Daniel TS Tan, HT Khor, William HS Low, Ahmad Ali, Abdul Gapor; Effect of a Palm-Oile-Vitamin E Concentrate on the Serum and Lipoprotein Lipids in Humans.

PDF Product Details Click here to download the product details in PDF format.

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